PeproTech。重组人瘦素Recombinant Human LeptinProduct DetailsCatalog Number: 300-27
Description:
Encoded by the ob (obese) gene, Leptin is an adipose-derived cytokine that suppresses appetite and increases thermogenesis. Leptin exerts its anorectic effect via signaling through a hypothalamic receptor termed OB-R. Leptin has been shown to reduce body weight, food consumption, and plasma glucose levels in various in vivo models. Recombinant Human Leptin is a 16.0 kDa protein containing 147 amino acid residues. Source: E.coli
Synonyms: Obesity protein (OB)
AA Sequence: MVPIQKVQDD TKTLIKTIVT RINDISHTQS VSSKQKVTGL DFIPGLHPIL TLSKMDQTLA VYQQILTSMP SRNVIQISND LENLRDLLHV LAFSKSCHLP WASGLETLDS LGGVLEASGY STEVVALSRL QGSLQDMLWQ LDLSPGC
Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity: PeproTech's Human Leptin is biologically active in the ob/ob mouse obesity model. The ob/ob mice were treated via intraperitoneal injection once daily at a dose of 5 µg Leptin/gm of body weight for 7 days. Significant effects on body weight, food consumption, and plasma glucose levels were observed compared to saline-treated controls.
Bacteria, Chicken, Human, Monkey, Mouse, Rat
Research Interest
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Immune System 
Inflammation 
Neurobiology 
Wound Healing 
Angiogenesis/Cardiovascular 
Apoptosis
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